The use of pentoxifylline is contraindicated during pregnancy. It is necessary to resolve the issue of termination of breastfeeding or cancellation trenbolone acetate buy of pentoxifylline therapy, given its importance to the mother.
Dosing and Administration
Inside, after a meal, without chewing, drinking plenty of water. The drug is administered at 400 mg (1 tablet) 2-3 times a day. The maximum daily dose -1200 mg. The course of treatment -. On the advice of a doctor
duration of treatment and dosage regimen established by your doctor individually, depending on the clinical picture of the disease and the resulting therapeutic effect.
The clinical effect is achieved within 2-4 weeks, but treatment is recommended to continue at least for 8 weeks to adequately assess efficacy.
patients with chronic renal insufficiency (creatinine clearance less than 10 ml / min.) is necessary to reduce the dose by half.
In patients on hemodialysis, it is recommended to begin treatment with a daily dose of 400 mg, followed by gradual dose escalation (no earlier than 4 days) until the usually recommended.
Side effect On the part of the central and peripheral nervous system: headache, dizziness, anxiety, sleep disorders, convulsions. For the skin and subcutaneous fat: flushing of the face, “tides” of blood to the skin of the face and upper chest, swelling , increased fragility of nails. From the digestive system: dry mouth, anorexia, atony bowel, nausea, vomiting, diarrhea, increased activity of “liver” enzymes, alkaline phosphatase, cholestatic hepatitis, exacerbation of cholecystitis. cardio-vascular system: tachycardia, arrhythmia, cardialgia, the progression of angina, lower blood pressure. On the trenbolone acetate buy part of the hemostatic system and of hematopoiesis: leukopenia, thrombocytopenia, pancytopenia, bleeding from vessels in the skin, mucous membranes of the stomach membranes, bowel, gipofibrinogenemia. from the senses: blurred vision, scotoma, Allergic reactions: itching skin, skin flushing, urticaria, angioedema, anaphylactic shock. Other: hypoglycemia.
Overdose symptoms: weakness, sweating, nausea, cyanosis, dizziness, decreased blood pressure, tachycardia, fainting, drowsiness or agitation, arrhythmia, hyperthermia, areflexia, loss of consciousness, tonic-clonic seizures, signs of gastrointestinal bleeding (vomiting-type “coffee grounds . “) Treatment: gastric lavage, followed by administration of activated charcoal inside. Symptomatic therapy: measures aimed at maintaining respiratory function and blood pressure; urgent measures for bleeding.
Interaction with other drugs
Pentoxifylline may increase the effects of agents that reduce blood pressure (angiotensin-converting enzyme (ACE) inhibitors, nitrates). Pentoxifylline may increase the effects of drugs that affect blood clotting (indirect and direct anticoagulants, thrombolytics), antibiotics (including cephalosporins – tsefamandola, tsefaperazon, tsefotetan)., Valproe-acid
Ciprofloxacin increases the concentration of pentoxifylline in plasma, therefore recommended reduce the concentration of pentoxifylline twice.
Ketorolac increases in prothrombin time and the risk of bleeding. The risk of bleeding is increased as well, while taking with meloxicam.
Cimetidine increases the concentration of pentoxifylline in plasma (the risk of side effects). Other trenbolone acetate buy H2 receptor blockers (famotidine, ranitidine and nizatidine) to a lesser extent affect the metabolism of pentoxifylline. Co-administration with other xanthines can lead to excessive nervous excitement.
Hypoglycemic action of insulin or oral hypoglycemic agents may be enhanced when taking pentoxifylline (increased risk of hypoglycaemia). There must be strict monitoring of these patients.
In some patients, concomitant use of pentoxifylline and theophylline may lead to increased levels of theophylline. This can lead to an increase or enhance the adverse effects associated with theophylline.
Treatment should be under the control of blood pressure. In patients with diabetes, taking hypoglycemic agents, the appointment of large doses can cause pronounced hypoglycemia (dose correction is required). When assigning simultaneously with anticoagulants should be carefully monitored for indicators of blood coagulation.
In patients who have recently had surgery, requires systematic monitoring of hemoglobin levels and hematocrit.
The dose should be reduced in patients with low and unstable blood pressure.
Older people may need to decrease dose (increased bioavailability and reduced clearance rate).
The safety and efficacy of pentoxifylline in children are not well understood. Smoking may trenbolone acetate buy reduce the therapeutic efficacy of the drug.